Herguijuela de la Sierra is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castilla y León. It is located 86 kilometres from the provincial capital city of Salamanca and has a population of 299 people. It is known, besides for its and other towns in the area's quaint old village air, for having a several hundred year old beech tree nearby, one of two in all of western-central Spain.
The municipality covers an area of 31.52 km².
It lies 800 metres above sea level.
The post code is 37619.
The Sierra de Francia Park is situated in the municipality.